Two sample MR report
HLA-DRB5_Alveolar Macrophages against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | -0.2319622 | 0.2504650 | 0.4521505 |
| Weighted median | 4 | -0.1109893 | 0.0309251 | 0.0003320 |
| Inverse variance weighted | 4 | -0.1099325 | 0.0258452 | 0.0000210 |
| Simple mode | 4 | -0.0909566 | 0.0426108 | 0.1224777 |
| Weighted mode | 4 | -0.1267072 | 0.0442075 | 0.0642500 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.3755772 | 2 | 0.8287899 |
| Inverse variance weighted | 0.6155083 | 3 | 0.8928731 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0416058 | 0.0849396 | 0.6727151 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.5e-05 | 2e-07 | TRUE | 0.5059512 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
